化疗在胆道恶性肿瘤围手术期应用的意义探讨

Exploring the significance of chemotherapy in the perioperative application of biliary tract carcinomas

胆道恶性肿瘤的恶性程度高,预后极差,根治性切除是目前唯一可能治愈胆道恶性肿瘤的方法。虽然近几年靶向治疗和免疫治疗发展迅速,但化疗在胆道恶性肿瘤围手术期治疗的基石地位依然无法被取代。围手术期化疗目的包括术前缩小肿瘤体积,使患者获得手术切除的机会和提高根治性切除率,以及术后清除残留肿瘤细胞、预防肿瘤复发等。近年来,不断有学者探索了以化疗为基础的联合治疗模式,以增强围手术期治疗效果,进一步改善患者预后。本文从根治性手术围手术期的化疗方案及临床试验进展的角度,探讨了化疗在胆道恶性肿瘤围手术期的应用价值。

Biliary tract cancer is extremely malignant with a poor prognosis.At the moment,the only curative method available is radical resection.Targeted and immunotherapy are currently advancing rapidly,but chemotherapy still holds a key role in the perioperative treatment of biliary cancer.Perioperative chemotherapy aims to decrease tumor volume prior to surgery so that patients can have their tumors surgically removed or have a higher radical resection rate.It also aims to remove any remaining tumor cells after surgery and prevent the growth of new tumors.Combination treatments based on chemotherapy have been increasingly investigated in recent years to improve perioperative care and patient survival.From the point of view of chemotherapy regimens and clinical trial success in the perioperative phase of radical surgery,the value of chemotherapy in the perioperative period of biliary tract cancer was explored in this paper.