超高剂量率放疗氧消耗假说的研究进展

Research progress on the oxygen depletion hypothesis of ultra-high dose rate radiotherapy

超高剂量率(FLASH)放疗是近年来肿瘤放射治疗领域最前沿的研究方向之一。实验表明,FLASH放疗能在保持与临床常规剂量率放疗同等肿瘤控制率的同时,显著减少正常组织中的放射损伤。氧消耗反应被认为是FLASH效应的关键机制之一。本文梳理了氧消耗反应的发现、实验证据及反应原理,总结了其测量手段和生物效应建模方法的研究进展,还讨论了正常组织与肿瘤氧消耗的差异性。

In recent years,ultra-high dose rate(FLASH)radiotherapy has become one of the most advanced research topics in the field of radiotherapy.Experimental data indicate that FLASH radiotherapy can significantly reduce the irradiation damage in normal tissues while being as effective as clinical conventional dose rate radiotherapy in tumor control.The oxygen depletion hypothesis is considered as one of the key mechanisms underlying the FLASH effect.In this article,research progress on the discovery,experimental evidence and reaction principle of oxygen depletion was reviewed,the measurement methods and biological effect modeling methods of the oxygen depletion hypothesis were summarized,and the oxygen depletion difference between normal tissue and tumor was also discussed.