黄永生教授治疗室性期前收缩的用药规律研究

Medication Regularity of Professor Huang Yongsheng in the Treatment of Premature Ventricular Beats

目的分析黄永生教授治疗室性期前收缩的用药规律。方法收集2012—2021年黄永生教授于长春中医药大学附属医院国医堂门诊诊治的室性期前收缩患者232例,涉及232首中药处方,157味中药。采用中医传承辅助平台(V2.5),统计中药使用频次,分析中药组合、中药关联规则及核心中药,基于复杂系统熵聚类分析提取新方组合。结果157味中药中使用频次≥30次的中药40味,使用频次≥100次的中药9味,依次为蝉蜕、僵蚕、紫石英、酸枣仁、磁石、合欢、九节菖蒲、百合、白附子。以中药组合使用频次进行降序排列,共得到17个使用频次≥80次的中药组合,24条中药关联规则,9味核心中药,分别为蝉蜕、紫石英、僵蚕、合欢、九节菖蒲、酸枣仁、百合、白附子、磁石。基于复杂系统熵聚类分析,共得到治疗室性期前收缩的新方组合2首,分别为“降香-水蛭-丹参-檀香”“紫石英-淫羊藿-制附子-巴戟天-龙齿”。结论黄永生教授是在蝉蜕、僵蚕、紫石英、酸枣仁、磁石、合欢、九节菖蒲、百合、白附子9味中药的基础上加减化裁治疗室性期前收缩,以达到调整阴阳治其本、缓急止悸治其标的治疗目的;此外,本研究还提取出2个新方组合,为室性期前收缩的临床遣方用药提供了新的思路。

Objective To analyze the medication regularity of Professor Huang Yongsheng in the treatment of premature ventricular beats.Methods A total of 232 patients with premature ventricular beats diagnosed and treated by Professor Huang Yongsheng in the Outpatient Department of Guoyitang,the Affiliated Hospital of Changchun University of Chinese Medicine from 2012 to 2021 were collected,involving 232 traditional Chinese drugs prescriptions and 157 traditional Chinese drugs.The Chinese medicine inheritance auxiliary platform(V2.5)was used to count the frequency of use of traditional Chinese drugs,analyze the combination of traditional Chinese drugs,the association rules of traditional Chinese drugs and the core traditional Chinese drugs,and the new prescription combination was analyzed by complex system entropy cluster analysis.Results Among the 157 traditional Chinese drugs,40 traditional Chinese drugs were used above or equal 30 times,and 9 traditional Chinese drugs were used above or equal 100,which followed by cicadae periostracum,bombyx batryticatus,fluoritum,ziziphi spinosae semen,magnetitum,albizzia julibrissin,anemone altaica,lilii bulbus,typhonii rhizoma.According to the descending order of the use frequency of traditional Chinese drugs combinations,17 traditional Chinese drugs combinations with using frequency of≥80,24 association rules of traditional Chinese drugs,and 9 core traditional Chinese drugs were obtained,which were cicadae periostracum,fluoritum,bombyx batryticatus,albizzia julibrissin,anemone altaica,ziziphi spinosae semen,lilii bulbus,typhonii rhizoma,magnetitum.Based on the complex system entropy cluster analysis,two new prescription combinations for the treatment of premature ventricular beats were obtained,which were"dalbergiae odoriferae lignum-leeches-salvia miltiorrhiza-santali albi lignum","fluoritum-epimedii folium-aconite preparation-morindae officinalis radix-dens draconis".Conclusion Professor Huang Yongsheng in the treatment of premature ventricular beats based on the addition and subtraction of 9 traditional Chinese drugs,which are cicadae periostracum,bombyx batryticatus,fluoritum,ziziphi spinosae semen,magnetitum,albizzia julibrissin,anemone altaica,lilii bulbus,typhonii rhizoma,in order to achieve the adjustment of Yin and Yang to treat its root,slow and urgent to stop palpitations to treat its target treatment;in addition,this study also extracted two new prescription combinations,which provided new ideas for the clinical prescription of premature ventricular beats.