早产儿发生脑室周围-脑室内出血机制的研究进展

Research Progress on the Mechanism of Periventricular-Intraventricular Hemorrhage in Premature Infants

脑室周围-脑室内出血(PVH-IVH)是早产儿常见的一种神经系统疾病,易造成多种并发症及后遗症,且临床诊治效果不佳。明确早产儿发生PVH-IVH的机制是目前该领域研究的热点和重点。大量证据表明,早产儿室管膜下胚胎生发基质(GM)和脑血流(CBF)自动调节系统发育情况与PVH-IVH发生密切相关。本文综述了早产儿发生PVH-IVH的机制,以期增加研究者和临床医生对PVH-IVH的认识,并为临床诊疗提供思路。

Periventricular-intraventricular hemorrhages(PVH-IVH)is a common nervous system disease in premature infants,which is easy to cause a variety of complications and sequelae,and has poor clinical diagnosis and treatment effect.Clarifying the mechanism of PVH-IVH in premature infants is the focus of research in this field.A large amount of evidence shows that the development of the auto-regulating system of subependymal embryonic germinal matrix(GM)and cerebral blood flow(CBF)in premature infants is closely related to the occurrence of PVH-IVH.This article reviews the mechanism of PVHIVH in premature infants,in order to improve the understanding of researchers and clinicians on PVH-IVH,and provide ideas for clinical diagnosis and treatment.