摘要
广谱高效的小分子药物是应对新型冠状病毒感染(COVID-19)及未来可能爆发疫情的重要武器。天然产物是药物先导化合物的重要来源,在抗COVID-19的药物研发中得到了广泛关注。本文综述了抗新型冠状病毒(SARS-CoV-2)药物的关键靶点和具有抗SARS-CoV-2活性的天然产物的研究进展,以期为抗SARS-CoV-2药物的研发提供参考。
The broad-spectrum small molecule antiviral drugs are important weapons to deal with COVID-19 and possible future outbreaks.Natural products are significant sources of lead compounds for drugs,and have received extensive attention in the development of drugs against COVID-19.In this paper the key targets of anti-SARS-CoV-2 drugs and the research progress of natural products with anti-SARS-CoV-2 activity were reviewed,in order to provide insights into the development of anti-SARS-CoV-2 drugs.
作者
杨娩玲
宋乐天
叶冰
程玉森
高升华
刘新泳
展鹏
YANG Mian-ling;SONG Le-tian;YE Bing;CHENG Yu-sen;GAO Sheng-hua;LIU Xin-yong;ZHAN Peng(Department of Medicinal Chemistry,Key laboratory of Chemical Biology(Ministry of Education),School of Pharmaceutical Sciences,Shandong University,Jinan 250012,China)
出处
《中国药物化学杂志》
CAS
2023年第3期191-216,共26页
Chinese Journal of Medicinal Chemistry
基金
山东省杰出青年基金项目(ZR2020JQ31)
中国博士后科学基金面上基金项目(2021M702003)
广东省基础与应用基础研究基金区域联合基金青年基金项目(2021A1515110740)。
