外周血NLR、CEA、D二聚体水平在胃癌根治术患者预后评估中的价值

Evaluation Value of Peripheral Blood NLR,CEA and D-dimer for Prognosis of Patients Underwent Radical Gastrectomy

目的探究胃癌根治术患者外周血中性粒细胞淋巴细胞比值(NLR)、癌胚抗原(CEA)、D-二聚体水平在预后评估中的价值。方法回顾性分析66例胃癌根治术患者的临床资料,对全体研究对象进行为期1年的随访并评估其预后。通过调取医院信息系统(Hospital information system)收集患者住院期间外周血NLR、CEA以及D-二聚体数据,分别采用单因素回归分析以及Logistic多因素回归分析探究其与研究对象胃癌根治术后预后的相关性。结果预后不良组与预后良好组患者在NLR>4、CEA>6 U/mL、D-二聚体呈升高趋势方面具有显著差异(P<0.05);Logistic多因素回归分析结果显示,NLR>4以及CEA>6 U/mL是胃癌根治术预后不良的独立危险因素(P<0.05)。结论胃癌患者NLR、CEA以及D-二聚体水平与胃癌根治术预后均存在关联,其中NLR>4及CEA>6 U/mL可视为影响胃癌根治术预后的独立危险因素。

Objective To explore the evaluation value of peripheral blood neutrophil-to-lymphocyte ratio(NLR),carcinoembryonic antigen(CEA)and D-dimer for prognosis of patients undergoing radical gastrectomy.Methods The clinical data of 66 patients with radical gastrectomy were retrospectively analyzed.All were followed up for 1 year to evaluate prognosis.The levels of peripheral blood NLR,CEA and D-dimer were collected by hospital information system during hospitalization.The correlation between the above indexes and prognosis was analyzed by univariate analysis and Logistic multivariate regression analysis.Results There were significant differences in NLR>4,CEA>6 U/mL and D-dimer increasing trend between poor prognosis group and good prognosis group(P<0.05).Logistic regression analysis showed that NLR>4 and CEA>6 U/mL were independent risk factors for poor prognosis after radical gastrectomy(P<0.05).Conclusion NLR,CEA and D-dimer are correlated with prognosis after radical gastrectomy.NLR>4 and CEA>6 U/mL are independent risk factors of prognosis.