多发性骨髓瘤患者骨髓细胞中CD269、CD317的表达及其意义

Expression and Significance of CD269 and CD317 in Bone Marrow Cells of Patients with Multiple Myeloma

目的分析白细胞分化抗原269(CD269)、分化抗原簇317(CD317)在多发性骨髓瘤(MM)患者骨髓细胞中的表达及临床意义。方法将56例MM患者纳入观察组,另外选取同期经骨髓穿刺证明为骨髓功能正常的非血液系统病症患者60例划入对照组。对比两组骨髓细胞内CD269、CD317相对表达量;同时收集所有MM患者的年龄、性别、体重指数(BMI)、细胞学类型、复发情况、临床分期等一般资料,分析CD269、CD317表达与其临床病理特征的关系。结果观察组CD269[(0.67±0.21)]、CD317[(1.46±0.38)]相对表达量高于对照组[(4.35±0.89)、(4.21±0.75)],有统计学差异(P<0.05);CD269、CD317表达与MM患者年龄、性别、BMI、细胞学类型、复发无关(P>0.05);CD269、CD317表达与MM患者临床分期有关(P<0.05)。结论CD269、CD317在MM患者的骨髓细胞内呈高表达,且与患者临床分期有关,可能参与疾病的发生与发展。

Objective To analyze the expression and clinical significance of leukocyte differentiation antigen 269(CD269)and differentiation antigen cluster 317(CD317)in bone marrow cells of patients with multiple myeloma(MM).Methods 56 patients with MM were included in the observation group,and 60 patients with non-hematological diseases proved to be normal by bone marrow puncture were included in the control group.Compare the relative expression of CD269 and CD317 in bone marrow cells of the 2 groups;At the same time,the age,sex,body mass index(BMI),cytological type,recurrence,clinical stage and other general data of all MM patients were collected to analyze the relationship between the expression of CD269 and CD317 and the clinicopathological characteristics.Results The relative expression of CD269[(0.67±0.21)]and CD317[(1.46±0.38)]in the observation group was significantly higher than that in the control group[(4.35±0.89)and(4.21±0.75)](P<0.05);The expression of CD269 and CD317 was not related to the age,sex,BMI,cytological type and recurrence of MM patients(P>0.05);The expression of CD269 and CD317 was related to the clinical stage of MM patients(P<0.05).Conclusion CD269 and CD317 are highly expressed in the bone marrow cells of MM patients,which are related to the clinical stage of patients,and may participate in the occurrence and development of disease.