甲状腺乳头癌组织中KLF5、TAZ、UHRF1的表达水平及其临床意义

Expression Levels of KLF5,TAZ and UHRF1 in Papillary Thyroid Carcinoma and Their Clinical Significance

目的探讨甲状腺乳头癌组织中KLF5、TAZ、UHRF1的表达水平及其临床意义。方法选取甲状腺乳头癌患者150例,所有研究对象均同意术中留取病灶组织标本以及配对的癌旁组织标本。观察甲状腺乳头癌组织中KLF5、TAZ、UHRF1的表达及与甲状腺乳头癌临床病理参数的关系以及KLF5、TAZ、UHRF1表达间的相关性。结果甲状腺乳头状癌组织中KLF5、TAZ、UHRF1蛋白阳性表达率(75.33%、70.00%、64.00%)均高于癌旁组织,差异均具有统计学意义(P<0.05)。KLF5、TAZ、UHRF1表达与肿瘤临床分期、肿块大小、淋巴结转移和甲状腺外侵犯相关(P<0.05),与患者年龄、性别及有无多灶性无关(P>0.05)。KLF5蛋白表达分别与TAZ、UHRF1蛋白表达呈正相关(γ=0.594,0.491,P均<0.05),TAZ蛋白表达与UHRF1蛋白表达呈正相关(γ=0.486,P<0.05)。结论甲状腺乳头癌组织中KLF5、TAZ、UHRF1的表达均上调,均与临床分期、肿块大小、淋巴结转移、甲状腺外侵犯有关。

Objective To investigate the expression levels of KLF5,TAZ and UHRF1 in thyroid papillary carcinoma and their clinical significance.Methods A total of 150 patients with thyroid papillary carcinoma were selected.All subjects agreed to take focal tissue specimens and paired paracancer tissue specimens during the operation.To observe the expression of KLF5,TAZ and UHRF1 in thyroid papillary carcinoma and the relationship between the expression of KLF5,TAZ and UHRF1 and clinicopathologic parameters of thyroid papillary carcinoma.Results The positive expression rates of KLF5,TAZ and UHRF1 proteins in papillary thyroid carcinoma tissues(75.33%,70.00%,64.00%)were higher than those in paracarpal tissues,with statistical significance(P<0.05).The expressions of KLF5,TAZ and UHRF1 were correlated with clinical stage,tumor size,lymph node metastasis and external thyroid invasion(P<0.05),but not with age,gender or multifocal(P>0.05).KLF5 protein expression was positively correlated with TAZ and UHRF1 protein expression(γ=0.594,0.491,both P<0.05),and TAZ protein expression was positively correlated with UHRF1 protein expression(γ=0.486,P<0.05).Conclusion The expressions of KLF5,TAZ and UHRF1 in papillary carcinoma were up-regulated,which were related to clinical stage,mass size,lymph node metastasis and extrathyroid invasion.