中医药防治糖皮质激素性骨质疏松症的研究进展

Research progress in the prevention and treatment of glucocorticoid-induced osteoporosis by traditional Chinese medicine

糖皮质激素是治疗肾病综合征的常用药物,但是长期大量使用会出现多种并发症,其中骨质疏松症是最常见的并发症之一,如何采取有效防治措施避免或减轻激素引起的骨质疏松症十分关键。中医学认为,肾主骨生髓,肾精亏虚、肾阴阳失调是该病的发病关键。中医药可以通过滋阴清热、温补脾肾、调理阴阳等法辨证论治减轻糖皮质激素性骨质疏松症。近年来诸多临床研究已经表明,中医药在防治糖皮质激素性骨质疏松症方面取得显著效果,探讨其有关机制的实验研究方面也有一定进展,但目前仍然处于探索阶段。本文将近年来糖皮质激素性骨质疏松症的中医药防治的有关研究进展予以综述,以期为临床治疗提供科学的理论依据。

Glucocorticoids are commonly used in the treatment of nephrotic syndrome,but long-term and massive use of glucocorticoids will lead to a variety of complications,among which osteoporosis is one of the most common complications.How to take effective prevention and treatment measures to avoid or reduce hormone-induced osteoporosis is very critical.According to traditional Chinese medicine,kidney dominating bone and bone produces bone marrow,the deficiency of kidney essence,and yin-yang disharmony of kidney are the key factors of the disease.Traditional Chinese medicine can treat glucocorticoid-induced osteoporosis based on syndrome differentiation by nourishing yin and clearing heat,warmly invigorating spleen and kidney,and coordinating yin and yang.In recent years,many clinical studies have shown that traditional Chinese medicine has achieved remarkable effects in the prevention and treatment of glucocorticoid-induced osteoporosis,and some progress has been made in the experimental research to explore its related mechanism,but it is still in the stage of exploration.This article reviews the progress in the prevention and treatment of glucocorticoid-induced osteoporosis by traditional Chinese medicine in recent years,in order to provide scientific theoretical basis for clinical treatment.