氧化三甲胺与慢性肾脏病及其并发症关系的研究进展

Research progress on the relationship between trimethylamine-N-oxide and chronic kidney disease and its complications

随着对“肠-肾轴”研究的不断深入,肠道菌群的代谢化合物氧化三甲胺与慢性肾脏病之间的联系成为现如今国内外学者的研究热点,为慢性肾脏病的防治提供新靶点。本文通过对近几年氧化三甲胺与慢性肾脏病的关系,及其通过诱导氧化应激、促发炎症反应促进心血管疾病、认知功能损害、腹膜炎、脑血管疾病等并发症的发生发展作一综述,拟为慢性肾脏病及其相关并发症的临床防治提供参考思路。

With the deepening of the research on the“gut-kidney axis”,the relationship between trimethylamine-N-oxide,the metabolic compound of intestinal flora,and chronic kidney disease has become a research hotspot for scholars at home and abroad,providing a new target for the prevention and treatment of chronic kidney disease.This paper reviews the relationship between trimethylamine-N-oxide and chronic kidney disease in recent years,and the promotion of cardiovascular disease,cognitive impairment,peritonitis,cerebrovascular disease,and other complications through inducing oxidative stress and inflammatory response,in order to provide reference ideas for the clinical prevention and treatment of chronic kidney disease and its related complications.