慢性偏头痛的磁共振成像研究进展

Research progress in magnetic resonance imaging of chronic migraine

慢性偏头痛是一种致残性神经系统疾病,导致患者严重的生活负担。为阐明慢性偏头痛发生发展机制,近年来出现了越来越多的相关性研究。结构磁共振和功能磁共振以其非入侵性的优点被很多研究者所接受,在本病的研究上取得了突破性进展。相关研究发现慢性偏头痛患者在大脑的疼痛相关区域存在脑区异常,包括白质微结构破坏,皮质层厚度变薄,灰质、脑区体积和功能网络的改变等,这些可能与偏头痛的发生和慢性化相关。本文观察近5年慢性偏头痛的结构磁共振和功能磁共振的相关研究,归纳总结其中重点内容,以期为本病机制的阐述、临床诊断和疗效评估提供科学依据。

Chronic migraine is a disabling neurological disease that causes severe living burden on patients.In recent years,to elucidate the pathogenesis of chronic migraine,more and more studies have been conducted on the pathogenesis.Structural magnetic resonance imaging and functional magnetic resonance imaging with its non-invasive advantages accepted by many researchers,in the disease research has made a breakthrough.Related studies found that chronic migraine patients in the brain pain-related brain abnormalities,including white matter microstructure destruction,cortical layer thickness thinning,gray matter,brain volume,and functional network changes,these may be related to the occurrence and chronicity of migraine.This paper observes the relevant studies on structural magnetic resonance imaging and functional magnetic resonance imaging of chronic migraine in recent 5 years,and summarizes the key contents to provide scientific basis for the elaboration of the mechanism,clinical diagnosis,and efficacy evaluation of the disease.