circRNA对妊娠中母体生殖器官和胚胎发育的作用

Effects of circRNAs on maternal reproductive organs and embryo development during pregnancy

环状RNA(circRNAs)在妊娠过程中起到重要的调节作用,这种调节作用主要表现为对卵巢和子宫等生殖器官及胚胎发育过程的调节。目前关于circRNAs在癌症中发挥重要调节作用的研究较多,而妊娠过程中胚胎种植及发育分化与癌症有着类似的相关分子机制,但是针对circRNAs在妊娠过程中调节作用的研究较少。本文调研了有关circRNAs在妊娠过程中发挥调节作用的最新文献,研究circRNAs如何在卵母细胞发育、胚胎植入及胚胎发育过程中进行调节,探索circRNAs在妊娠过程中的应用,有助于寻找疾病新的分子标志物,也为不孕不育诊疗拓宽思路。

circularRNA(circRNAs)play an important regulatory role in pregnancy,this regulation is mainly manifested in the regulation of ovarian and uterus and other reproductive organs,and embryonic development process.At present,there are many studies on the important regulatory role of circRNAs in cancer,embryogenesis and differentiation during pregnancy have similar molecular mechanisms with cancer.However,there are few studies on the regulatory role of circRNAs during pregnancy.This paper reviewed the latest literature on the regulatory role of circRNAs in pregnancy,to investigate how circRNAs regulates oocyte development,embryo implantation,and embryo development.Exploring the application of circRNAs in pregnancy is helpful to search for new molecular markers of disease,and also broaden the thinking of infertility diagnosis and treatment.