脓毒症相关性脑病早期诊断与治疗研究新进展

New progress in the investigation of early diagnosis and treatment of sepsis-related encephalopathy

脓毒症相关性脑病(SAE)是指由全身炎症反应引起的弥散性脑功能障碍。SAE具有高发病率、高致残率和高病死率的特点,给社会、家庭带来了沉重的负担。SAE发病机制复杂,临床表现为不同程度的功能和认知障碍,目前还没有确切的影像学和实验室诊断标准,早期诊断困难。SAE没有确切的治疗方案,非药物预防和管理是治疗SAE的关键,包括炎症控制、血流动力学、代谢因素、药物使用、环境因素等。临床上重视早期诊断,有效管理上述潜在可控的因素,积极控制原发病,可能有助于改善患者预后和长期生存质量。

Sepsis-associated encephalopathy(SAE)refers to the diffuse brain dysfunction caused by systemic inflammatory response.SAE has the characteristics of high morbidity,disability and mortality,which would bring a heavy burden to society and families.The pathogenesis of SAE is complex,and its clinical manifestations are different degrees of functional and cognitive dysfunction.At present,there is no definite imaging and laboratory diagnostic standard,so it is difficult to make early diagnosis.There is no definite treatment plan for SAE.Non-drug prevention and management is the key to treat SAE,including inflammation control,hemodynamics,metabolic factors,medication,environmental factors,etc.Clinically,paying attention to early diagnosis,effectively managing the above-mentioned potential controllable factors and actively controlling the primary disease may be helpful to improve the prognosis and long-term quality of life of patients.