院内血流感染患者病原菌分布研究进展

Research progress on the distribution of pathogenic bacteria in patients with nosocomial bloodstream infection

血流感染是一种严重的全身感染性疾病,因其具有病情进展迅速、治疗难度大、病死率高等特点,已得到临床医师广泛关注。病原菌侵袭进入血液循环内繁殖、生长,诱导大量炎症递质和细胞因子释放,进而引起感染及全身炎症反应。相关研究表明,院内血流感染病原菌分布广泛,且存在病种、年龄等差异,尤其是院内抗生素的广泛应用会对血流感染患者病原菌分布造成一定影响。因此,本研究将详细论述院内血流感染患者病原菌分布情况及临床诊疗的研究进展。

Bloodstream infection is a serious systemic infectious disease,which has been widely concerned by clinicians because of its rapid progress,difficult treatment and high mortality,etc.Pathogenic bacteria invade into the blood circulation,reproduce and grow,induce the release of a large number of inflammatory mediators and cytokines,and then cause infection and systemic inflammatory reaction.Relevant researches show that the pathogenic bacteria of nosocomial bloodstream infection are widely distributed,and there are differences in diseases and ages.The wide application of antibiotics in the hospital,one of the commonest problems,will have certain impact on the distribution of pathogenic bacteria in patients with bloodstream infection.Therefore,this research will discuss in detail the distribution of pathogenic bacteria in patients with nosocomial bloodstream infection and the research progress of clinical diagnosis and treatment.