铁代谢异常及铁死亡与多囊卵巢综合征关系的研究进展

Relationship between abnormal iron metabolism, ferroptosis and polycystic ovary syndrome

铁代谢参与机体许多重要生理活动,铁死亡是一种新型程序性细胞死亡方式,人们对铁代谢、铁死亡在多囊卵巢综合征(PCOS)中的作用了解局限。在患有PCOS的患者中发现铁超载现象,且铁代谢也对PCOS患者的激素、代谢、生殖产生直接或间接影响。铁死亡亦可造成PCOS患者代谢紊乱。目前,PCOS的发病机制不明,通过对铁代谢、铁死亡的了解阐明其与PCOS之间的关系,以期探索出对PCOS的治疗新靶点。

Iron metabolism is involved in many important physiological activities of the body,and ferroptosis is a new type of programmed cell death.Little is known about the role of iron metabolism and ferroptosis in polycystic ovary syndrome(PCOS).Iron overload has been found in patients with PCOS,and iron metabolism has direct or indirect effects on hormones,metabolism,and reproduction in patients with PCOS.Ferroptosis can also cause metabolic disorders in patients with PCOS.At present,the pathogenesis of PCOS is unknown.By understanding iron metabolism,ferroptosis and their relationship with PCOS are useful in exploring new targets for the treatment of PCOS.