摘要
牛病毒性腹泻病毒(bovine viral diarrhea virus,BVDV)众多基因亚型毒株的流行及其宿主谱的扩大干扰着BVDV防控工作。欧洲国家采用全面检测和扑杀BVDV阳性牛的方法达到一定防控效果,但结合我国实际生产情况,使用疫苗防控BVDV仍是最优策略。深入了解病毒感染过程中BVDV蛋白与宿主免疫系统之间的“博弈”,将有助于研究人员在疫苗研发过程中有效规避抗原候选蛋白可能对免疫效果造成的干扰。此外,大力开发低成本、高效力的新型疫苗(如表位肽疫苗和病毒样颗粒疫苗)可以在整合病毒免疫优势抗原表位的基础上加强BVDV相关疫苗的生物安全性,满足用疫苗防控BVDV的要求。鉴于此,本文对BVDV蛋白免疫学功能与特性的研究以及BVDV疫苗开发的现状进行综述,以期为BVDV疫苗研发以及BVDV防控提供一些理论指导。
The prevalence of numerous genetic subtypes strains of bovine viral diarrhea virus(BVDV)and the expansion of its host spectrum interfere with the prevention and control of BVDV.European countries have adopted the measure of comprehensive detection and culling of BVDV-positive cattle and achieved a certain prevention and control effect,but considering the actual production situation in China,vaccination is still the optimal strategy.An in-depth understanding of the‘game’between BVDV proteins and the host immune system during virus infection will help researchers to effectively avoid the potential interference of antigen candidate proteins on immune effects in the term of vaccine development.In addition,vigorously developing low-cost,high-efficiency new-type vaccines(such as epitope peptide vaccine and virus-like particle vaccine)can enhance the biosafety of BVDV vaccines based on integrating viral immunodominant antigenic epitopes,and meet the requirements for the prevention and control of BVDV with vaccines.Thus,in order to provide proof-of-concept towards the development of BVDV vaccine and BVDV prevention and control,this paper reviews the researches on the immunological function and characteristics of BVDV proteins and the current situation of BVDV vaccine development.
作者
李易聪
蒲飞洋
冯茜莉
汪梦竹
赵泽阳
张德荣
马忠仁
周建华
LI Yicong;PU Feiyang;FENG Xili;WANG Mengzhu;ZHAO Zeyang;ZHANG Derong;MA Zhongren;ZHOU Jianhua(Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission,Biomedical Research Center,Northwest Minzu University,Lanzhou 730030,China;Gansu Tech Innovation Center of Animal Cell,Biomedical Research Center,Northwest Minzu University,Lanzhou 730030,China;College of Life Science and Engineering,Northwest Minzu University,Lanzhou 730010,China;Lanzhou Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Lanzhou 730046,China)
出处
《畜牧兽医学报》
CAS
CSCD
北大核心
2023年第4期1381-1391,共11页
ACTA VETERINARIA ET ZOOTECHNICA SINICA
基金
优秀青年团队培育项目(31920220069)
西北民族大学引进人才科研项目(xbmuyjrc202225)
国家自然科学基金(31302100)。
