朱氏调经促孕方加减治疗卵巢储备功能下降的临床观察

Clinical Observation on the Treatment of Diminished Ovarian Reserve Function withZhu’s Modified Prescription for Regulating Menstruation and Promoting Pregnancy

目的观察朱氏调经促孕方加减治疗卵巢储备功能下降(diminished ovarian reserve,DOR)患者的临床疗效。方法将90例患者按照随机数字表法分为2组。对照组45例予雌二醇/雌二醇地屈孕酮片;治疗组45例予朱氏调经促孕方加减治疗。2组均连续服药3个月后统计血清卵泡刺激素(FSH)、黄体生成素(LH)、血清卵泡刺激素与黄体生成素比值(FSH/LH)、雌二醇(E2)、抗缪勒管激素(AMH)水平及窦卵泡个数(AFC),并观察2组治疗前后中医证候积分改善情况,统计临床疗效。结果治疗后2组经期、经色、经量、腰骶酸痛、小腹胀痛、头晕耳鸣、痛经、性欲减退积分及总分均有明显降低(P<0.05),且治疗组积分(除经期、性欲减退外)与对照组相比较,差异有统计学意义(P<0.05);2组治疗后FSH、LH、FSH/LH、E2、AMH水平及AFC个数组内比较均改善(P<0.05),治疗组FSH、FSH/LH、E2与对照组治疗后比较差异有统计学意义(P<0.05);2组总有效率比较,差异无统计学意义(P>0.05)。结论朱氏调经促孕方加减能够有效改善DOR患者的激素水平,促进卵巢功能的恢复,缓解临床症状,具有良好的临床疗效。

Objective:To observe the clinical efficacy of diminished ovarian reserve(DOR)patients treated with Zhu’s modified prescription for regulating menstruation and promoting pregnancy.Methods:90 patients were divided into two groups according to random number table method.45 patients in the control group were given estradiol/didrogesterone tablets and 45 patients in the treatment group were treated with Zhu’s prescription for regulating menstruation and promoting pregnancy.The serum follicle stimulating hormone(FSH),luteinizing hormone(LH),ratio of serum follicle stimulating hormone to luteinizing hormone(FSH/LH),estradiol(E2),anti-Muller-tube hormone(AMH)levels and number of sinus follicles(AFC)of the two groups were collected after 3 months of continuous administration.The improvement of TCM syndrome scores before and after treatment in both groups was observed and the clinical efficacy was analyzed.Results:After treatment,the menstrual period,menstrual color,menstrual volume,lumbosacral soreness,lower abdominal distension pain,dizziness,tinnitus,dysmenorrhea,decreased libido scores and total scores of the two groups were significantly decreased(P<0.05).In comparison of the scores of the treatment group(except menstrual period and decreased libido)with the control group,the difference was statistically significant(P<0.05).After treatment,the levels of FSH,LH,FSH/LH,E2,AMH and AFC in the two groups were improved(P<0.05),and there were statistically significant differences in FSH,FSH/LH,E2 between the two groups(P<0.05).There was no significant difference in the total effective rate between the two groups(P>0.05).Conclusion:Zhu’s modified prescription for regulating menstruation and promoting pregnancy can effectively improve the hormone level of patients with DOR,promote the recovery of ovarian function,relieve clinical symptoms,and have good clinical efficacy.