基于BODIPY的荧光探针检测活性氧的研究进展

Recent Developments of BODIPY-based Fluorescent Probes for the Detection of Reactive Oxygen

活性氧(ROS)是一种重要的含氧化学活性物质,与各种生理过程密切相关。但过量的ROS可能会导致诸多疾病,如心血管疾病、神经退行性疾病甚至癌症等,因此有效的识别和检测ROS具有重要意义。氟硼二吡咯亚甲基(BODIPY)由于其独特的光物理性质、优异的光化学稳定性以及可行的衍生化,近年来被广泛应用于检测ROS。针对不同的活性氧进行分类,主要综述了近5年来国内外基于BODIPY荧光探针用于检测ROS的研究现状,并展望了BODIPY荧光探针检测ROS的发展方向,旨在为今后研究ROS在生理和病理过程中的作用提供一定的理论参考。

Reactive oxygen species(ROS)are important oxygen-containing chemical active substance,which are closely related to various physiological processes.But excessive ROS may cause many diseases,such as cardiovascular disease,neurodegenerative disease,and even cancer.Thus the effective identification and detection of ROS is of great importance.Due to the unique photophysical properties,excellent photochemical stability and feasible derivatization,boron-fluoropyrrolidine methylene(BODIPY)has been widely used for ROS detection in recent years.This article classified different ROS,mainly reviewed the research status of BODIPY-based fluorescence probes for ROS detection at home and abroad in the past five years,prospected the development direction of BODIPY-based fluorescence probe for detection of ROS,and provided some reference value for future research on the role of ROS in the physiopathological process.