玉米赤霉烯酮对动物繁殖性能的毒性作用及其机制

Toxic Effects of Zearalenone on Animal Reproductive Performance and Its Mechanism

玉米赤霉烯酮(ZEA)一种由镰刀菌属产生的次级代谢物,化学结构与内源性雌激素相似,因此,ZEA可通过与雌激素竞争性结合雌激素受体,导致动物机体生殖激素代谢紊乱,诱发生殖器官形变及功能障碍,严重危害动物繁殖系统,解决ZEA污染问题己经成为当务之急。本文对ZEA的理化特性、毒性作用等进行综述,以期为有效缓解ZEA毒性及提高动物繁殖性能、促进畜牧业健康发展提供理论依据。

Zearalenone(ZEA)is a secondary metabolite produced by Fusarium spp.Its chemical structure is similar to that of endogenous estrogen.In this way,ZEA can competitively bind estrogen receptors to estrogen,leading to metabolic disorders of reproductive hormones in animals,and inducing deformation and dysfunction of reproductive organs.The problem of ZEA pollution has become an urgent matter.This article reviewed the physicochemical properties and toxic effects of ZEA,in order to provide a theoretical basis for effectively alleviating ZEA toxicity,and improving animal reproductive performance as well as promoting the healthy development of animal husbandry.