巨噬细胞在移植后慢性排斥反应中的作用研究进展

Research progress on the role of macrophages in post-transplantation chronic rejection

器官移植是治疗终末期器官病变的最佳方法,然而排斥反应仍然是影响移植物存活的重要因素。目前,针对急性排斥反应的治疗方法效果良好,但对慢性排斥反应仍缺乏有效的治疗手段,长期慢性排斥反应可能导致移植物失功,严重影响移植物的长期存活率。近年来,巨噬细胞在慢性排斥反应中的作用逐渐受到关注。本文对慢性排斥反应的主要病理变化、参与慢性排斥反应巨噬细胞的多样性及功能差异、巨噬细胞参与慢性排斥反应的作用及机制进行综述,并总结巨噬细胞相关慢性排斥反应治疗的研究进展,以期为巨噬细胞在器官移植术后慢性排斥反应中的作用研究提供参考。

Organ transplantation is the optimal treatment for end-stage organ failure.Nevertheless,rejection remains an important factor affecting the allograft survival.At present,acute rejection may be effectively treated,whereas no effective interventions are available for post-transplantation chronic rejection.Long-term chronic rejection may lead to graft failure and severely affect long-term survival rate of allografts.In recent years,the role of macrophages in posttransplantation chronic rejection has gradually captivated increasing attention.In this article,main pathological changes of chronic rejection,the diversity and functional differences of macrophages involved in chronic rejection,and the role and mechanism of macrophages in chronic rejection were reviewed,and research progresses on macrophage-related treatment for chronic rejection were summarized,aiming to provide reference for the study of macrophages in post-transplantation chronic rejection.