免疫检查点抑制剂治疗晚期肝细胞癌患者研究进展

Application of immune checkpoint inhibitors in treatment of patients with advanced hepatocellular carcinoma

免疫检查点抑制剂是一种癌症免疫治疗药物,通过改善肿瘤周围免疫微环境而达到抗肿瘤目的。肝细胞癌是最常见的原发性肝癌类型,疾病晚期的治疗效果差。免疫检查点抑制剂治疗晚期肝细胞癌具有一定的疗效。本文对免疫检查点抑制剂在晚期肝细胞癌应用的作用机制、治疗进展和不良事件作一综述。

Immune checkpoint inhibitor is a kind of cancer immunotherapy agents,which has anti-tumor activities by improving immune microenvironment around the tumors.The hepatocellular carcinoma(HCC)is the most common primary liver cancer,and the treatment efficacy of advanced disease is poor.The immune checkpoint inhibitors have a certain effects on advanced HCC.In this article,we will review the mechanism,treatment and adverse events of immune checkpoint inhibitors in treating patients with advanced HCC.