西罗莫司治疗SLE的作用机制

Sirolimus in the treatment of SLE

系统性红斑狼疮(SLE)是以免疫紊乱为主要特征的系统性疾病,肾脏损害和皮肤红斑是其主要的临床表征,同时可能伴随关节炎、血小板减少、血管炎或神经系统病变等。西罗莫司是哺乳动物雷帕霉素靶蛋白(mTOR)的靶向抑制剂,具有抗真菌、抗肿瘤、抗纤维化和免疫抑制的功能。本文就西罗莫司在SLE治疗中的机制及应用进行综述,以期为SLE的治疗提供参考。

Systemic lupus erythematosus(SLE)is a systemic disease characterized by immune dysfunction.Kidney damage and skin erythematosus are its main clinical manifestations,and may be accompanied by arthritis,thrombocytopenia,vasculitis,or neurological disease.Sirolimus is a targeted inhibitor of mammalian target of rapamycin(mTOR)with antifungal,antitumor,antifibrotic,and immunosuppressive functions.This article reviews the mechanism and application of sirolimus in the treatment of SLE,in order to provide evidence for the treatment decisions of SLE.