摘要
自身炎症性疾病(SAIDs)是一组因固有免疫失调导致全身炎症的遗传性、异质性疾病。肿瘤坏死因子-α(TNF-α)在急慢性炎症中起到关键作用,TNF-α抑制剂广泛用于类风湿关节炎、银屑病关节炎、炎性肠病等疾病,能有效控制SAIDs患者的全身炎症和改善症状,表现出起效快,耐受性好的特点。本文综述TNF-α抑制剂治疗SAIDs的机制及研究进展。
Systemic autoinflammatory diseases(SAIDs)are a group of hereditary,heterogeneous disorders characterized by systemic inflammation due to innate immune dysfunction.Since tumor necrosis factor-α(TNF-α)plays an essential role in both acute and chronic diseases,TNF-α inhibitors have been widely used in diseases like rheumatoid arthritis,psoriatic arthritis,and inflammatory bowel diseases.With characteristics of rapid-onset efficacy and good tolerance,it is also effective for systemic inflammation control and symptoms improvement of SAIDs patients.The article provides an overview of the mechanisms and advances of TNF-α inhibitors in the treatment of SAIDs.
作者
张婧元
沈敏
ZHANG Jing-yuan;SHEN Min(Department of Rheumatology and Clinical Immunology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College/Key Laboratory of Rheumatology and Clinical Immunology,Ministry of Education/State Key Laboratory of Complex Severe and Rare Diseases/National Clinical Research Center for Dermatologic and Immunologic Diseases(NCRC-DID),Beijing 100730,China)
出处
《中华临床免疫和变态反应杂志》
CAS
2023年第1期68-73,共6页
Chinese Journal of Allergy & Clinical Immunology
基金
北京自然科学基金(7192170)
中央高水平医院临床科研专项(2022-PUMCH-D-002,2022-PUMCH-B-013)。
