地佐辛注射液引起药物依赖的病例分析及文献复习

Drug Dependence Induced by Dizocine Injection and Literature Review

目的探讨地佐辛产生药物依赖的临床特点及处理措施。方法回顾性分析1例梗阻性腹痛患者使用地佐辛治疗的情况及全程药学监护,并对地佐辛药物依赖性相关文献复习。结果患者青年女性,乙状结肠造瘘术后不全肠梗阻伴腹痛,长期大剂量使用地佐辛注射液产生依赖性,该例患者依赖程度相对较轻,戒断症状不严重。采用逐渐减少地佐辛用量后患者摆脱药物依赖。结论地佐辛进行镇痛治疗时应合理用药,加强监护,如有药物依赖及时对症处理。

Objective To investigate the clinical characteristics and disposal of drug dependence of dizocine.Methods The pharmaceutical care of a patient with obstructive abdominal pain treated with dizocine was retrospectively analyzed,and the related literature was reviewed to find out more about drug dependence induced by dizocine.Results A young female with incomplete intestinal obstruction and abdominal pain after sigmoid ostomy and treated with a large dose of dizocine injection developed drug dependence and withdrawal symptoms.Drug dependence was lessened by gradually reducing the dose of dizocine.Conclusion It is recommended that rational use of dizocine and pharmaceutical care should be ensured during analgesic treatment.Immediate symptomatic treatment should be provided once the patient shows drug dependence on dizocine.