血管支架植入对血管平滑肌细胞的影响

Impact of Vascular Stent Implantation on Vascular Smooth Muscle Cells

支架植入是冠心病的一种重要治疗方式,植入过程伴随着血管壁的损伤和机械性能的改变,进而导致血管平滑肌细胞进行一系列复杂的表型变化,包括从中膜向内膜的迁移和增殖,以及从收缩表型转变为合成表型等,从而导致新生内膜的增殖和支架内再狭窄的发生。恢复血管生理稳态、保持血管平滑肌细胞表型稳定是经皮冠状动脉介入治疗的最终理想,故探究血管支架植入后血管平滑肌细胞发生的生物反应,将有助于新一代心血管器械研发,帮助临床决策的制定。现对血管支架植入对血管平滑肌细胞的生物学影响进行综述。

As an essential treatment of coronary artery disease,stent implantation always accompanies damaging to the vascular wall and mechanical properties altering,which in turn lead to complex changes of phenotypic switching in vascular smooth muscle cells,including its proliferation and the migration from media to the intimal,as well as the switching from the contractile phenotype to synthetic phenotype,causing the occurrence of neointimal hyperplasia and in-stent restenosis.The ultimate goal of percutaneous coronary intervention is to restore vascular hemostasis and maintain the stable contractile phenotype.Therefore,exploring the biological response of vascular smooth muscle cells after vascular stenting will promote the development of a newer generation of cardiovascular devices and help make clinical decisions.This article aims at reviewing the biological effects of vascular stent implantation on vascular smooth muscle cells.