早发冠心病发病机制相关基因多态性研究进展

Gene Polymorphisms Related to Pathogenesis of Premature Coronary Artery Disease

早发冠心病是指发病年龄男性≤55岁、女性≤65岁,发生于青年的冠心病,多伴有家族史,遗传因素的影响更为重要。随着基因检测技术的进步,人们试图从基因多态性的角度揭示早发冠心病的发生,为其预防和治疗提供依据。目前对早发冠心病致病基因的寻找大多集中在内皮损伤、炎性反应、脂质代谢异常、血栓形成等主要发病机制,现基于国内外研究进展,拟从发病机制的角度论述多种类型的基因多态性与早发冠心病风险之间的关系。

Premature coronary artery disease(PCAD)refers to the onset of coronary artery disease in young people whose age is male less than 55 years old and female less than 65 years old,often accompanied by family history,and the influence of genetic factors is more important.With the progress of gene detection technology,people try to reveal the occurrence of PCAD from the perspective of gene polymorphism so as to provide basis for its prevention and treatment.At present,the search for PCAD pathogenic genes is mostly focused on endothelial injury,inflammatory response,abnormal lipid metabolism,thrombosis and other major pathogenesis.Based on domestic and foreign research progress,this paper intends to discuss the relationship between different types of gene polymorphism and the risk of PCAD from the perspective of pathogenesis.