肠道病毒在系统性红斑狼疮发病中的作用

Gut viruses in the pathogenesis of systemic lupus erythematosus

Systemic lupus erythematosus(SLE)is an autoimmune disease characterized by the production of autoantibodies targeting selfantigens and has a complex etiology including both genetic and environmental factors[1].Recently,alterations of the intestinal microbiota have received increasing attention[2]and efforts have begun to correct the dysbiotic environment to treat patients with SLE[3].However,besides bacteria,the microbiome contains other types of organisms including viruses which may infect both host cells and gut bacteria.It is accepted that elements of the microbiome through interactions with intestinal non-lymphoid and lymphoid cells account for the homeostasis of the immune system and the maintenance of gut physiology[4].Due to a series of technical obstacles,including the low representation of virus genomes in microbiome and the paucity of sufficient viral genome sequence database,disease-associated changes of the gut virome in SLE have remained under the radar although viruses have long been considered as one of potent triggers of SLE[5].