乳腺肿瘤放射治疗作用下的数值模拟分析

Numerical Simulation Analysis of Radiotherapy for Breast Tumor

目的:数值建模以模拟乳腺肿瘤细胞放射治疗下的生长浸润,并进行不同放疗频率分析。方法:建立放疗前后乳腺肿瘤细胞生长浸润的时空演变数学模型,采用线性二次模型模拟肿瘤细胞放疗存活率,对比分析常规放疗作用下乳腺肿瘤细胞时空演变及不同放疗频率对其治疗的影响。结果:乳腺肿瘤常规放射治疗时空演变符合临床趋势,所建立模型真实可靠,且总放射剂量不变情况下,不同放疗频率对治疗结果的影响不大。结论:放疗数值模拟与临床表征基本相符,方法简便安全,是临床肿瘤放射治疗的有效模拟手段。

Objective:To simulate the growth and infiltration of breast tumor cells under radiotherapy by numerical modeling,and analyze the different radiotherapy frequencies.Methods:A mathematical model of the spatiotemporal evolution of the growth and infiltration of breast tumor cells before and after radiotherapy was established.The linear quadratic model was used to simulate the survival rate of tumor cells after radiotherapy.The spatiotemporal evolution of breast tumor cells under conventional radiotherapy and the effect of different radiotherapy frequencies on their treatment were compared and analyzed.Results:The spatiotemporal evolution of conventional radiotherapy for breast tumor was in line with the clinical trend.The established model was true and reliable.With the total radiation dose unchanged,different radiotherapy frequencies had little effect on the treatment results.Conclusion:The numerical simulation of radiotherapy is basically consistent with the clinical characterization.The method is simple and safe,and is an effective simulation method for clinical tumor radiotherapy.