基于数据挖掘分析中成药治疗阳痿用药规律

Analysis of Administration Rules of Chinese Patent Medicine for Impotence Based on Data Mining

目的:基于数据挖掘分析中成药治疗阳痿用药规律。方法:筛选整理《中华人民共和国卫生部药品标准:中药成方制剂》《中国药典》《中国药典临床用药须知:中药成方制剂卷》《国家中成药标准汇编》《国家药品标准:新药转正标准》中有关治疗阳痿的中成药,分析中成药中药物的使用频次、药物功效、性味归经,并采用复杂网络、因子分析和关联规则分析方法总结中成药治疗阳痿的用药规律。结果:共筛选出处方86首,涉及中药176味。使用频次较高的中药有枸杞子、熟地黄、菟丝子、淫羊藿、鹿茸、当归、肉苁蓉等。药物以补虚药、收涩药、利水渗湿药为主;多归肾、肝、脾经;药性以温、平性多见;药味以甘、辛为主。关联分析得到最核心药物组合为熟地黄-山药-茯苓-枸杞子。复杂网络分析结果得到当归-黄芪-甘草-白术-白芍-锁阳、鹿茸-人参-远志-酸枣仁、枸杞子-五味子-覆盆子-山药-茯苓-肉桂-补骨脂等6个模块组合。聚类分析得到熟地黄-当归-巴戟天-肉苁蓉-杜仲、茯苓-山药-补骨脂-五味子-枸杞子、黄芪-甘草、鹿茸-人参等组合。因子分析贡献率最高的药物组合为巴戟天-杜仲-茯苓-肉苁蓉。结论:中成药治疗阳痿的核心药物为枸杞子、熟地黄、菟丝子、淫羊藿、鹿茸、当归、肉苁蓉等,治疗以补肾固精、滋养肝脾为主,兼以利水、清热、温中,临床常用无比山药丸、麦味地黄丸、五子衍宗丸等方加减辨证治疗。

Objective:To observe the administration rules of Chinese patent medicine for impotence based on data mining.Methods:The Chinese patent medicine used for impotence in Drug Standard of Ministry of Public Health of the People's Republic of China:Chinese Traditional Compound Medicine,Chinese Pharmacopoeia,Pharmacopoeia of People's Republic of China:Clinical Medication Notice,National Standard Compilation of Chinese Patent Medicine,National Drug Standard:Standard of New Drug Becoming Official were screened and sorted.The usage frequency,effects,nature,flavors and meridian entries of Chinese medicines included into Chinese patent medicine were analyzed,and the administration rules of Chinese patent medicine for impotence were summarized by complex network analysis,factor analysis and association rule analysis.Results:A total of 86 prescriptions were included,with 176 Chinese medicinals involved.The mostly used Chinese medicines are Lycii Fructus,Rehmanniae Radix Praeparata,Cuscutae Semen,Epimedh Folium,Cervi Cornu Pantotrichum,Angelicae Sinensis Radix and Cistanches Herba.Among them,deficiency-supplementing medicinals,astringent medicinals and dampnessdraining diurectic medicinals take the majority;the main meridian entries of Chinese medicinals are the kidney meridian,the liver meridian,and the spleen meridian;Chinese medicinals with warm and balanced nature account for the most;the flavor is mostly acrid and sweet.In line with the association rule analysis,the core combination of medicinals is Rehmanniae Radix Praeparata-Dioscoreae Rhizoma-Poria-Lycii Fructus.According to the complex network analysis,a total of six model combinations,including Angelicae Sinensis Radix-Astragali Radix-Glycyrrhizae Radix et Rhizoma-Atractylodis Macrocephalae Rhizoma-Paeoniae Radix Alba-Cynomorii Herba,Cervi Cornu Pantotrichum-Ginseng Radix et Rhizoma-Polygalae Radix-Ziziphi Spinosae Semem and Lycii Fructus-Schisandrae Chinensis Fructus-Rubi Fructus-Dioscoreae Rhizoma-Poria-Cinnamomi Cortex-Psoraleae Fructus.The cluster analysis suggested four combinations of Chinese medicinals,including Rehmanniae Radix Praeparata-Angelicae Sinensis Radix-Morindae Officinalis Radix-Cistanches Herba-Cortex Eucommiae,Poria-Dioscoreae Rhizoma-Psoraleae Fructus-Schisandrae Chinenisis Fructus-Lycii Fructus,Astragali Radix-Glycyrrhizae Radix et Rhizoma and Cervi Cornu Pantotrichum-et Rhizoma Ginseng Radix.The combination of Chinese medicnals with the highest contribution rate in the factor analysis is Morindae Officinalis Radix-Eucommiae Cortex-Poria-Cistanches Herba.Conclusion:The core Chinese medicinals in the treatment of impotence by Chinese patent medicine are Lycii Fructus,Rehmanniae Radix Praeparata,Cuscutae Semen,Epimedh Folium,Cervi Cornu Pantotrichum,Angelicae Sinensis Radix and Cistanches Herba.The main treatment principle is to tonify the kidney and secure essence,and enrich and nourish the liver and spleen,combined with promoting urination,clearing heat and warming the middle energizer.In clinical,modified prescriptions,such as Wubi Shanyan Pills,Meiwei Dihuang Pills and Five-Seed Progeny Pills can be used for treatment based on syndrome differentiation.