清热祛湿方加减辅助兰索拉唑治疗慢性萎缩性胃炎临床研究

Clinical Study on Modified Qingre Qushi Prescription Assisting Lansoprazole for Chronic Atrophic Gastritis

目的:观察清热祛湿方加减辅助兰索拉唑治疗慢性萎缩性胃炎的临床疗效及对氧化应激指标的影响。方法:采用随机数字表法将98例慢性萎缩性胃炎患者分为对照组、观察组各49例。对照组口服兰索拉唑片治疗,观察组在对照组基础上加用清热祛湿方加减治疗。比较2组治疗前后中医证候评分、氧化应激指标[超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、丙二醛(MDA)]、胃功能指标、炎症因子[肿瘤坏死因子-α(TNF-α)、C-反应蛋白(CRP)、白细胞介素-6(IL-6)]水平,并评估2组临床疗效及不良反应发生情况。结果:观察组治疗总有效率93.88%,高于对照组83.67%(P<0.05)。治疗后,2组MDA、TNF-α、CRP、IL-6、胃蛋白酶原(PG)Ⅱ水平及中医证候评分均较治疗前降低(P<0.05),SOD、GSH-Px、PGⅠ、胃泌素-17(G-17)水平升高(P<0.05),且观察组MDA、TNF-α、CRP、IL-6、PGⅡ水平及中医证候评分低于对照组(P<0.05),SOD、GSH-Px、PGⅠ、G-17水平高于对照组(P<0.05)。对照组不良反应发生率14.29%,高于观察组4.08%(P<0.05)。结论:清热祛湿方加减辅助兰索拉唑治疗慢性萎缩性胃炎疗效确切,能减轻患者氧化应激损伤,降低炎症因子水平,安全性较高。

Objective:To observe the clinical effect of modified Qingre Qushi Prescription assisting Lansoprazole for chronic atrophic gastritis and its effect on oxidative stress indexes.Methods:A total of 98 cases of patients with chronic atrophic gastritis were divided into the control group and the observation group according to the random number table method,with 49 cases in each group.The control group was treated with the oral administration of Lansoprazole Tablets,and the observation group was additionally treated with modified Qingre Qushi Prescription based on the treatment of the control group.Traditional Chinese medicine(TCM)syndrome scores,oxidative stress indexes including superoxide dismutase(SOD),glutathione peroxidase(GSH-Px)and malondialdehyde(MDA),inflammatory factors including tumor necrosis factor-α(TNF-α),C-reactive protein(CRP)and interleukin-6(IL-6)before and after treatment were compared between the two groups.The clinical effects and the incidence of adverse reactions in the two groups were evaluated.Results:The total effective rate of treatment was 93.88%in the observation group,higher than that of 83.67%in the control group(P<0.05).After treatment,the levels of MDA,TNF-α,CRP,IL-6,and pepsinogen(PG)Ⅱand the TCM syndrome scores in the two groups were decreased when compared with those before treatment(P<0.05),and the levels of SOD,GSH-Px,PGⅠand gastrin-17(G-17)were increased(P<0.05);the levels of MDA,TNF-α,CRP,IL-6,and PGⅡand the TCM syndrome scores in the observation group were lower than those in the control group(P<0.05),and the SOD,GSH-Px,PGⅠand G-17 levels in the observation group were higher than those in the control group(P<0.05).The incidence of adverse events was 14.29%in the control group,higher than that of 4.08%in the observation group(P<0.05).Conclusion:Modified Qingre Qushi Prescription assisting Lansoprazole for chronic atrophic gastritis has a definite curative effect,and can alleviate oxidative stress damage and reduce the levels of inflammatory factors in patients with high safety.