年轻乳腺癌患者生育问题再认识

Reconsideration of fertility in young patients with breast cancer

年轻乳腺癌患者妊娠率远低于普通人群,与患者对肿瘤复发的担忧、化疗所致的卵巢功能减退、内分泌治疗周期漫长、缺乏专业化多学科协作团队保驾护航等因素相关。目前,有关年轻乳腺癌患者肿瘤治疗前实施生育力保存、治疗后成功妊娠并生产的数据有限。为顺利开展年轻女性乳腺癌患者生育力保存工作,促进患者身心健康和社会角色回归,提升其子代健康水平,本文就影响生育力的因素、生育力保存的合适人群和对乳腺癌预后的影响及乳腺癌生育力的保存时机、方式、恢复时机等作一述评。

The pregnancy rate of young breast cancer patients is far lower than that of the general population,which is possibly related to many factors such as patients'concern about tumor recurrence,ovarian dysfunction caused by chemotherapy,long endocrine treatment cycle,lack of professional multidisciplinary cooperation team and so on.At present,there is limited data on fertility preservation before tumor treatment and successful pregnancy and delivery after treatment for young breast cancer patients.In order to successfully carry out the fertility preservation of young female breast cancer patients,strengthen their physical and mental health,promote the return of social roles and improve the health level of their offsprings,this article reviews the factors affecting fertility,the appropriate population for fertility preservation,and the impact on the prognosis of breast cancer,as well as the timing and methods of fertility preservation and recovery opportunities in young women with breast cancer.