DNA甲基转移酶DNMT3A在人类常见病毒感染中的研究进展

Research Progress of DNA Methyltransferase DNMT3A in Viral Infection

DNA甲基转移酶(DNA methylationtransferases,DNMTs)是哺乳动物建立与维持基因甲基化的酶类家族,参与基因表达和调控等生物学过程。其中DNA甲基转移酶3A(DNA methyltransferase 3 Alpha,DNMT3A)是机体重要DNMTs之一,DNMT3A突变或异常表达所诱导的基因甲基化引起机体相关因子活性失调进而诱发疾病发生,DNMT3A介导的基因甲基化与人类常见病毒感染所致疾病密切相关。本篇综述从人类常见病毒感染宿主的角度出发,对DNMT3A在促进病毒感染与诱发疾病中的作用进行阐述,为进一步探究以DNMT3A为病毒感染性疾病治疗靶点提供参考和思路。

DNA methyltransferases(DNMTs) are a family of enzymes involved in establishment and maintenance of gene methylation in mammals. DNMTs are involved in the expression and regulation of genes.DNA methyltransferase 3A(DNMT3A) is one of the most important DNMTs. The mutation or abnormal expression induced gene methylation of DNMT3A, and may can lead to dysregulation of the activity of related factors and induce the occurrence of diseases. However, gene methylation mediated by DNMT3A is closely related to diseases due to infection by common human viruses. This article reviews the role of DNMT3A in promoting infection and inducing disease from the viewpoint of infection by common human viruses. It also provides a reference and concept for further exploration of the therapeutic targets of DNMT3A for infectious viral diseases.