薏苡附子败酱散治疗溃疡性结肠炎的研究进展

Yiyi Fuzi Baijiangsan in Treatment of Ulcerative Colitis:A Review

薏苡附子败酱散出自《金匮要略》,为治疗肠痈代表方,全方由薏苡仁、附子、败酱草3味药配伍而成,具有健脾温阳、清热祛湿解毒之效,是临床上治疗溃疡性结肠炎(UC)的常用方剂。UC是一种病变累及结直肠黏膜的慢性非特异性炎症性疾病,病因病机尚未十分明确,多与遗传、外界及肠道环境、免疫、感染等多种因素相关。动物实验及临床研究均表明薏苡附子败酱散治疗UC具有多靶点、多方位的优势。薏苡附子败酱及其中单味药的提取物均有防治UC的作用,目前薏苡附子败酱散治疗UC的作用研究机制主要集中于减轻肠道炎症反应、抗结直肠癌作用、缓解氧化应激、修复肠上皮细胞屏障、改善肠道菌群紊乱、抑制细胞凋亡、维持肠道免疫平衡等。临床上薏苡附子败酱散加减联合西药效果满意,能明显改善UC患者相关临床症状,并能延缓病情,提高患者生存质量,并具有安全性高、不良反应小等优势。其相关研究为UC的临床防治及薏苡附子败酱散对UC作用机制的后续探索提供了理论支持和数据支撑,同时也对中医药治疗UC的研究有重大意义。该文就薏苡附子败酱散对UC的防治及作用机制进行综述。

Yiyi Fuzi Baijiangsan is scattered from the Essentials from the Golden Cabinet(《金匮要略》)for the treatment of intestinal carbuncles.The whole prescription is composed of Coicis Semen,Aconiti Lateralis Radix Praeparata,and Patrinia scabiosifolia,with the effect of invigorating spleen,warming Yang,clearing heat,removing dampness,and detoxification,which is a commonly used prescription for the clinical treatment of ulcerative colitis(UC).UC is a chronic nonspecific inflammatory disease with lesions involving the colorectal mucosa,and the etiology is not yet very clear,which is mostly related to genetics,external and intestinal environment,immunity,infection,and other factors.Animal experiments and clinical studies have shown that Yiyi Fuzi Baijiangsan have the advantages of multi-target and multi-faceted treatment of UC.At present,the research mechanism of the treatment of UC is mainly focused on reducing intestinal inflammatory response,anti-colorectal cancer effect,alleviating oxidative stress,repairing the intestinal epithelial cell barrier,improving intestinal flora disorder,inhibiting apoptosis,maintaining intestinal immune balance,etc.Clinically,the combination of modified Yiyi Fuzi Baijiangsan and western medicine has a satisfactory effect,which can significantly improve the relevant clinical symptoms of patients with UC,delay the condition,and improve the quality of life of patients,with the advantages of high safety and small side effects.Its related research provides theoretical support and data support for the clinical prevention and treatment of UC and the follow-up exploration of the mechanism of Yiyi Fuzi Baijiangsan in the treatment of UC,and is also of great significance to the research on the treatment of UC with Chinese medicine.This paper reviewed the prevention and control mechanism of Yiyi Fuzi Baijiangsan in the treatment of UC.