磁振磁电疗法治疗湿热瘀阻型慢性前列腺炎/慢性盆底疼痛综合征的效果及对单核细胞趋化蛋白-1、血管细胞黏附因子-1的影响

Effect of magnetic resonance electromagnetic therapy on chronic prostatitis/chronic pelvic pain syndrome with dampness-heat and blood-stasis and its effect on monocyte chemotactic protein-1 and vascular cell adhesion molecule-1

目的观察磁振磁电疗法治疗湿热瘀阻型慢性前列腺炎/慢性盆底疼痛综合征(CP/CPPS)的效果及对单核细胞趋化蛋白-1(MCP-1)、血管细胞黏附因子-1(VCAM-1)水平的影响。方法选取广东省中医院珠海医院2021年1月至2022年1月的110例湿热瘀阻型CP/CPPS患者。按照随机数字表法将其分成对照组和试验组,每组55例。对照组予前列倍喜胶囊,试验组予磁振磁电疗法,治疗2个疗程。比较两组美国国立卫生研究院慢性前列腺炎症状积分指数(NIH-CPSI)评分,临床疗效,中医证候评分,中医证候疗效,前列腺液VCAM-1、MCP-1水平及不良反应发生情况。结果治疗后,两组NIH-CPSI评分及中医证候评分均低于治疗前,且试验组低于对照组(P<0.05)。试验组临床疗效优于对照组(P<0.05)。试验组的中医证候疗效优于对照组(P<0.05)。治疗后,两组前列腺液MCP-1、VCAM-1水平均低于治疗前,且试验组低于对照组(P<0.05)。两组均未见局部疼痛、皮肤潮红、水泡、全身不适等不良反应。结论磁振磁电疗法治疗湿热瘀阻型CP/CPPS效果显著,其作用机制可能与调节MCP-1、VCAM-1水平,激发免疫功能,抑制炎症有关。

Objective To observe the effect of magnetic resonance electromagnetic therapy on chronic prostatitis/chronic pelvic pain syndrome(CP/CPPS)with damp-heat and blood-stasis and its effect on monocyte chemotactic protein-1(MCP-1)and vascular cell adhesion molecule(VCAM-1).Methods A total of 110 CP/CPPS patients with damp-heat and blood-stasis treated in Guangdong Provincial Hospital of Chinese Medicine Zhuhai Hospital from January 2021 to January 2022 were selected.They were divided into experimental group and control group by random number table method,with 55 cases in each group.The control group was treated with Qianliebeixi Capsules and the experimental group was treated with magnetic resonance electromagnetic therapy,and the for two courses.National Institutes of Health chronic prostatic inflammation(NIH-CPSI),clinical efficacy,traditional Chinese medicine syndrome score,traditional Chinese medicine syndrome efficacy,prostatic fluid level of VCAM-1,MCP-1,and incidence of adverse reactions were compared between two groups.Results After treatment,the scores of NIH-CPSI and traditional Chinese medicine syndrome of two groups were lower than those before treatment, and experimental group was lower than control group (P<0.05). The clinical efficacy of experimental group was better than that of control group (P<0.05). The traditional Chinese medicine syndrome efficacy of experimental group was better than that of control group (P<0.05). After treatment, the levels of MCP-1 and VCAM-1 in two groups were lower than those before treatment, and experimental group was lower than control group (P<0.05). No adverse reactions such as local pain, rubefaction, blister, and general discomfort were observed in both groups. Conclusion Magnetic resonance electromagnetic therapy has a good effect in treating CP/CPPS with damp-heat and blood-stasis, and its mechanism may be related to regulating MCP-1 and VCAM-1 levels, stimulating immune function and inhibiting inflammation.