基于中医传承计算平台的感染后咳嗽组方规律分析

Analysis on the rules of post-infectious cough prescriptions based on Traditional Chinese Medicine Inheritance Computing Platform

目的探索感染后咳嗽中药配伍规律和组方思路,有效指导临床用药。方法检索中国知网、维普、万方数据库自1997年1月至2021年9月有关中医药治疗感染后咳嗽的文献,建立数据库,运用中医传承计算平台V3.0,进行药物频次、功效、性味、归经统计及药物间关联度分析,通过k-means聚类分析得出核心药物组合。结果最终纳入188个处方共涉及162种中药,筛选出30种高频次药物。162味中药的功效以化痰止咳平喘、解表、补虚类为主,药性以温、寒、平为主,药味中苦、辛、甘为主,主要归肺、脾、胃、心、肝经。通过关联规则分析得出24个常用的药物组合和28组关联药物,药物整体呈现出以“甘草-桔梗-紫菀-杏仁-荆芥-百部-白前-麻黄-陈皮”为核心的药物组合。基于聚类分析得出核心药组5个。结论感染后咳嗽中药处方具有以化痰止咳平喘、解表、补虚为主,温寒并用,以温药为要的用药特点及注重宣肃肺气的核心治法特点,为进一步探究感染后咳嗽临床用药规律及现代药理学研究提供理论基础。

Objective To explore the compatibility rules and formulation ideas of traditional Chinese medicine for post-infectious cough and to guide the clinical medication effectively.Methods Literature on the treatment of post-infectious cough by traditional Chinese medicine was retrieved from CNKI,VIP,and Wanfang Data from January 1997 to September 2021,and the database was established.The Traditional Chinese Medicine Inheritance Computing Platform V3.0 was used to carry out statistics of drug frequency,efficacy,nature and flavour,channel tropism and correlation analysis among drugs,and the core drug combination was obtained by k-means clustering analysis.Results A total of 188 prescriptions involving 162 kinds of traditional Chinese medicine were included,and 30 kinds of high-frequency drugs were screened out.The efficacy of 162 traditional Chinese medicine mainly includes dissipating phlegm,relieving cough,relieving dyspnea,relieving superficies,and tonifying deficiency classes.The medicinal natures were mainly warm,cold,and plain,and the medicinal flavours were mainly bitter,pungent,and sweet,and mainly attributed to the lung,spleen,stomach,heart,and liver channels.Through association rule analysis,24 commonly used drug combinations and 28 groups of associated drugs were obtained.As a whole,the drug combination with“Glycyrrhizae Radix Et Rhizoma-Platycodonis Radix-Asteris Radix Et Rhizoma-Armeniacae Semen Amarum-Schizonepetae Herba-Stemonae Radix-Cynanchi Stauntonii Rhizoma Et Radix-Ephedrae Herba-Citri Reticulatae Pericarpium”as the core.Five core drug groups were obtained based on cluster analysis.Conclusion The traditional Chinese medicine prescriptions for post-infectious cough is characterized by dissipating phlegm,relieving cough,relieving dyspnea,relieving superficies,and tonifying deficiency,combining warm and cold,taking warm medicine as the key,and focusing on the core treatment features of lung qi,which provides theoretical basis for further exploring the clinical medication law of post-infectious cough and modern pharmacological research.