单细胞测序技术在肝脏疾病中的研究进展

Research progress of single-cell sequencing technology in liver diseases

肝脏疾病是全球沉重的疾病负担之一,但鉴于其发病机制十分复杂,治疗选择相对受限,所以需要新技术对其发病机制进行深入研究。单细胞测序(SCS)作为一种新兴测序方法,通过对单个细胞的基因组、转录组和表观基因组测序,反映细胞间的异质性,进而揭示疾病发生和发展过程中的复杂机制。SCS在肝病研究中的应用将丰富我们对肝病发病机制的理解,为探索肝病的诊疗方法提供新方向。现主要对SCS技术在肝脏疾病中的研究进展予以综述。

Liver disease is one of the most burdensome diseases in the world.Therefore,new technologies are needed to study its pathogenesis in depth;however,because of its complex pathogenesis,there are relatively limited treatment options.Single-cell sequencing(SCS),as an emerging sequencing method,reflects the heterogeneity between cells by sequencing the genome,transcriptome,and epigenome of a single cell,thereby revealing the complex mechanisms of disease occurrence and development.The application of SCS in the study of liver diseases will enrich our understanding of the pathogenesis of liver diseases and provide a new direction for exploring the diagnosis and treatment.This article mainly reviews the research progress of SCS technology in liver diseases.