热休克蛋白90在肝细胞癌中的研究进展

Research Progress of Heat Shock Protein 90 in Hepatocellular Carcinoma

肝细胞癌中蛋白质稳态是其生长和转移的基础,Hsp90作为分子伴侣可维持多种促癌分子的稳定性,并抑制抑癌分子的活性,使蛋白质合成和降解之间保持平衡,致使癌细胞在恶劣微环境的持续刺激下依旧可以生存。然而,Hsp90抑制剂因在临床试验中表现出严重的不良反应,故迄今没有一种抑制剂获得FDA的批准。该篇文章阐述了Hsp90的结构、表达调控、伴侣循环以及Hsp90过表达与肝细胞癌之间的联系,旨在阐明Hsp90在肝细胞癌发生发展中的作用,为临床用药提供理论依据。

In hepatocellular carcinoma,protein homeostasis is the basis of its growth and metastasis.Hsp90,as a molecular chaperone,maintains the stability of various cancer-promoting molecules and inhibits the activity of cancer-inhibiting molecules to maintain a balance between protein synthesis and degradation,so that cancer cells can still survive under the continuous stimulation of harsh microenvironment.However,severe adverse reactions to Hsp90 inhibitors in clinical trials resulted in none of the inhibitors being approved by the FDA.This paper describes the structure,expression regulation,chaperone circulation of Hsp90 and the relationship between Hsp90 overexpression and hepatocellular carcinoma,in order to clarify the role of Hsp90 in the occurrence and development of hepatocellular carcinoma and provide theoretical basis for clinical drug use.