组蛋白去甲基化酶KDM3B结构、功能及其相关疾病研究进展

Research Progress in the Structure,Function of Histone Demethylase KDM3B and Its Related Diseases

表观遗传学是研究在DNA序列不变的前提下,其他机制异常引起基因表达改变并可遗传的学科。组蛋白甲基化/去甲基化修饰是表观遗传学的重要调控机制之一,是甲基化酶和去甲基化酶动态相互作用的结果,其中H3K9的甲基化和去甲基化是近年来研究最深入的组蛋白修饰之一。组蛋白去甲基化酶KDM3B包含一个JmjC结构域,并具有固有的H3K9去甲基化活性,能够特异性去除H3K9me1/2甲基化修饰,调控基因转录、DNA损伤修复,参与细胞增殖、细胞凋亡、干细胞干性维持、肿瘤和遗传病发生发展等。该文就组蛋白去甲基化酶KDM3B的结构、作用机制、生物学功能及其成为一个临床研究和治疗的潜在药理学靶点的可能性作一综述。

Epigenetics is a genetic discipline that studies the gene expression changes caused by abnormalities in other mechanisms under the premise of unchanged DNA sequence.Histone methylation/demethylation modification,as a result of the dynamic interaction of methylase and demethylase,is one of the important regulatory mechanisms of epigenetics.The methylation and demethylation of H3K9 is one of the most thoroughly studied histone modifications in recent years.KDM3B contains JmjC domain and has inherent H3K9 demethylation activity.It can specifically remove H3K9me1/2 methylation modification,regulate gene transcription,DNA damage repair,and participate in cell proliferation,cell apoptosis,maintenance of stem cell stemness,occurrence and development of tumors and genetic diseases.This article reviews the structure,mechanism of action,biological function of histone demethylase KDM3B in the pathogenesis and development of disease,and it is expected to be a potential drug target for clinical research and treatment.