X-盒结合蛋白1在脑缺血中的作用

Role of X-Box Binding Protein 1 in Cerebral Ischemia

X-盒结合蛋白(X-box binding protein 1,XBP1)是碱性亮氨酸拉链结构蛋白,在脑缺血引起的内质网应激反应中扮演着重要角色。XBP1在非内质网应激时以未剪接的X-盒结合蛋白1(X-box binding protein 1-unspliced,XBP1-u)的形式表达,在内质网应激期间表现为剪接的X-盒结合蛋白(X-box binding protein 1-spliced,XBP1-s)的形式。为了充分了解XBP1,该文将从XBP1的两种异构体的结构、分布、定位以及病理生理功能等方面进行综述,并重点探讨XBP1-s在脑缺血后激活氧连-N-乙酰葡萄胺修饰和葡萄糖调节蛋白-78表达以减少氧化应激损伤、促进缺血组织中的内皮细胞增殖保护脑微血管内皮细胞损伤以及调节细胞焦亡等方面的作用。

XBP1(X-box binding protein 1)is a basic leucine zipper structural protein,which plays an important role in the endoplasmic reticulum stress response after cerebral ischemia.XBP1 is expressed in the form of XBP1-u(X-box binding protein 1-unspliced)during non-ER(endoplasmic reticulum)stress,and in the form of XBP1-s(X-box binding protein 1-spliced)during ER stress.In order to fully understand XBP1,this article will review the structure,distribution,localization and pathophysiological functions of the two isomers of XBP1,and focus on the role of XBP1-s in activating the modification of oxo-N-acetylglucosamine,the expression of glucose regulatory protein-78 after cerebral ischemia to reduce oxidative stress damage,the injury of cerebral microvascular endothelial cells and cell apoptosis during cerebral ischemia.