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Astrocytes in Chronic Pain:Cellular and Molecular Mechanisms 被引量:6

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摘要 Chronic pain is challenging to treat due to the limited therapeutic options and adverse side-effects of therapies.Astrocytes are the most abundant glial cells in the central nervous system and play important roles in different pathological conditions,including chronic pain.Astrocytes regulate nociceptive synaptic transmission and network function via neuron–glia and glia–glia interactions to exaggerate pain signals under chronic pain conditions.It is also becoming clear that astrocytes play active roles in brain regions important for the emotional and memory-related aspects of chronic pain.Therefore,this review presents our current understanding of the roles of astrocytes in chronic pain,how they regulate nociceptive responses,and their cellular and molecular mechanisms of action.
出处 《Neuroscience Bulletin》 SCIE CAS CSCD 2023年第3期425-439,共15页 神经科学通报(英文版)
基金 supported by the Ministry of Science and Technology of China Brain Initiative Grant(2022ZD0204702) the National Natural Science Foundation of China(32030048 and 32100806) the Natural Science Foundation of the Higher Education Institutions of Jiangsu Province(21KJB310010).
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