空气细颗粒物造血毒性与生物学机制研究进展

Research progress on hematopoietic toxicity and biological mechanism of ambient fine particulate matters

近年来,空气细颗粒物(fine particulate matters,PM_(2.5))毒理与健康效应一直是环境化学领域的热点问题.流行病学和毒理学研究表明,除呼吸和心脑血管系统损伤外,PM_(2.5)还可对血细胞和造血器官产生不良影响.为此,本文简要回顾了机体造血过程,基于流行病学数据和毒理学实验结果综述了PM_(2.5)造血毒性,从氧化应激、炎症损伤和表观遗传修饰等方面归纳了生物学机制.

In recent years,the toxicological and health effects of ambient fine particulate matters(PM_(2.5))have been a hot topic in the field of environmental chemistry.In addition to respiratory and cardiovascular system damages,PM_(2.5) posed the adverse impacts on blood cell and hematopoietic organs.For this purpose,this paper briefly reviewed the hematopoietic process of organisms,introduced PM_(2.5)-induced hematopoietic toxicity based on epidemiological studies and toxicological experiments,and clarified biological mechanisms,mainly focusing on oxidative stress,inflammatory damage and epigenetic modification.