官窍正气鼻炎整体疗法用于慢性鼻-鼻窦炎的效果观察

Efficacy of Guanqiao Zhengqi holistic therapy for chronic rhinosinusitis

目的探讨官窍正气鼻炎整体疗法用于慢性鼻-鼻窦炎的治疗效果。方法选取2021年1月至2022年1月在山西省中西医结合医院及山西颐圣堂中医馆耳鼻喉科就诊的慢性鼻-鼻窦炎患者200例为研究对象,其中山西省中西医结合医院72例,山西颐圣堂中医馆128例,采用随机对照研究方法,以随机数字表法分为两组,每组100例。对照组给予糠酸莫米松鼻喷雾剂和盐酸左西替利嗪片,治疗组在对照组基础上予官窍正气鼻炎整体疗法治疗,两组疗程均为4周,跟踪随访3个月。治疗前后评估两组患者临床疗效、改良视觉模拟量表(VAS)评分、鼻内镜检查Lund.Kennedy评分以及糖皮质激素、抗白三烯使用时间。结果对照组总有效率为73.00%(73/100),治疗组为92.00%(92/100),治疗组有效率显著高于对照组(χ^(2)=18.45,P<0.001);治疗前两组患者VAS评分差异无统计学意义(Z=1.37,P=0.170),治疗后两组VAS评分差异有统计学意义(Z=-5.27,P<0.001);治疗前两组患者鼻内镜检查Lund.Kennedy评分差异无统计学意义(Z=-1.65,P=0.098),治疗后两组鼻内镜检查Lund.Kennedy评分差异有统计学意义(Z=-6.03,P<0.001);糖皮质激素及抗白三烯使用时间,治疗组明显短于对照组[10.00(10.00,14.00)d比42.00(28.00,70.00)d、7.00(7.00,7.00)d比21.00(14.00,26.25)d],差异有统计学意义(Z=-11.27,P<0.001、Z=-12.31,P<0.001)。结论在西医常规治疗的基础上,采用官窍正气鼻炎整体疗法治疗慢性鼻-鼻窦炎,能有效改善患者临床症状,并且有助于减少激素及抗白三烯的使用总量、缩短使用周期,提高治疗效果。

Objective To investigate the efficacy of Guanqiao Zhengqi holistic therapy in the treatment of chronic rhinosinusitis.Methods A total of 200 patients with chronic rhinosinusitis who received treatment in the Department of Otolaryngology,Shanxi Provincial Integrated Traditional Chinese Medicine and Western Medicine Hospital(n=72)and Shanxi Yishengtang Traditional Chinese Medicine Center(n=128)from January 2021 to January 2022 were included in this study.These patients were randomly assigned to undergo treatment either with mometasone furoate nasal spray and levocetirizine hydrochloride tablets(control group,n=100)or Guanqiao Zhengqi holistic therapy combined with mometasone furoate nasal spray and levocetirizine hydrochloride tablets(observation group).All patients were treated for 4 weeks and followed up for 3 months.Clinical efficacy,modified Visual Analogue Scale score,Lund-Kennedy endoscopy scoring system score,and duration of glucocorticoid and anti-leukotriene use were compared between the two groups.Results The total response rate in the observation group was significantly higher than that in the control group[92.00%(92/100)vs.73.00%(73/100),χ^(2)=18.45,P<0.001).There was no significant difference in the modified Visual Analogue Scale score between the two groups before treatment(Z=1.37,P=0.170).There was a significant difference in the modified Visual Analogue Scale score between the two groups after treatment(Z=-5.27,P<0.001).Before treatment,there was no significant difference in the Lund-Kennedy endoscopy scoring system score between the two groups(Z=-1.65,P=0.098)and the Lund-Kennedy endoscopy scoring system score differed significantly between the two groups after treatment(Z=-6.03,P<0.001).The duration of glucocorticoid and anti-leukotriene use in the observation group was significantly shorter than that in the control group[10.00(10.00,14.00)days vs.42.00(28.00,70.00)days,7.00(7.00,7.00)days vs.21.00(14.00,26.25)days,Z=-11.27,P<0.001,Z=-12.31,P<0.001).Conclusion Based on the conventional treatment with western medicine,Guanqiao Zhengqi holistic therapy for the treatment of chronic rhinosinusitis can effectively reduce clinical symptoms,reduce the dose of hormones and anti-leukotriene used,shorten the use cycle,and improve the therapeutic efficacy.