脑小血管病白质高信号相关性头晕的发病机制研究进展

Research progress in pathogenesis of white matter hyperintensity related dizziness in small cerebral vascular disease

随着神经影像技术的发展,脑小血管病已成为近年来国内外学者的研究热点,已明确其与认知减退、痴呆、步态不稳有关,然而最近研究发现伴有白质高信号的脑小血管病是老年人不明原因慢性头晕的主要病因,但二者相关机制尚不完全清楚,近期研究表明,可能与大脑神经网络离断、视觉依赖、脑组织结构异常引起眼动障碍、氧化应激调节障碍、脑血流自身调节障碍、前庭系统与情绪障碍相互影响等有关。

With the development of neuroimaging technology,cerebral small vessel disease has become a hot research topic in recent years.It has been clearly related to cognitive decline,dementia and gait instability.However,recent studies have found that small cerebral vascular disease with white matter hyperintensities is the main cause of chronic dizziness in the elderly,but the pathogenesis is not completely clear,which may be related to brain neural network disconnection,visual dependence,eye movement disorder caused by abnormal brain tissue structure,oxidative stress regulation disorder,cerebral blood flow self-regulation disorder,and the interaction mechanism between vestibular system and emotional disorder.