胆红素与多囊卵巢综合征相关性的研究进展

Research progress on the relationship between bilirubin and polycystic ovary syndrome

多囊卵巢综合征是一种常见的生殖内分泌代谢性疾病,其发病机制与炎症、胰岛素抵抗、代谢紊乱等密切相关。胆红素是机体内衰老红细胞破坏降解的终产物,除可用于评估肝功能损害以及有一定的细胞毒性之外,还有抗炎、抗氧化、改善脂质代谢紊乱等作用。研究发现人体内低水平胆红素与多囊卵巢综合征存在一定的相关性:多囊卵巢综合征患者体内的胆红素水平较低,而胆红素的抗炎、抗氧化性特点在多囊卵巢综合征发病中可能具有保护作用。

Polycystic ovary syndrome(PCOS)is a common reproductive endocrine and metabolic disease,and its pathogenesis is closely related to inflammation,insulin resistance,and metabolic disorders.Bilirubin is the final product of the destruction and degradation of senescent red blood cells in the body.In addition,bilirubin can be not only used to evaluate liver function damage and cytotoxicity,but also can anti-inflammatory,antioxidant,alleviate metabolic disorders,etc.Recently,studies have found a certain correlation between low levels of bilirubin and PCOS:the level of bilirubin in patients with PCOS is low,and the anti-inflammatory and antioxidant properties of bilirubin may play a protective role in the pathogenesis of PCOS.