心肌损伤标志物与老年脓毒症合并心功能障碍患者炎症因子及预后的相关性分析

Correlation Analysis of Myocardial Injury Markers with Inflammatory Factors and Prognosis in Elderly Sepsis Patients with Cardiac Dysfunction

目的:探讨心肌损伤标志物与老年脓毒症合并心功能障碍患者炎症因子及预后的相关性。方法:选取2022年1—8月于北京丰台医院急诊科抢救室就诊的100例老年脓毒症患者,按照是否有心功能障碍分为心功能障碍组44例与无心功能障碍组56例;研究结束后随访28 d,依据患者生存情况分为存活组83例及死亡组17例;比较各组B型利钠肽(BNP)、肌钙蛋白(cTnI)、降钙素原(PCT)、序贯器官衰竭评估(SOFA)评分的差异。采用Pearson相关系数分析BNP、cTnI与老年脓毒症合并心功能障碍患者的PCT、SOFA的相关性。结果:心功能障碍组BNP、cTnI、PCT及SOFA评分均高于无心功能障碍组,差异有统计学意义(P<0.05)。死亡组BNP、cTnI、PCT及SOFA评分高于存活组,差异有统计学意义(P<0.05)。老年脓毒症合并心功能障碍患者的BNP、cTnI与PCT、SOFA评分呈正相关(P<0.05)。结论:BNP、cTnI与老年脓毒症合并心功能障碍患者的炎症因子及预后呈正相关,临床可通过监测BNP、cTnI指标来改善预后。

Objective:To explore the correlation between myocardial injury markers and inflammatory factors and prognosis in elderly sepsis patients with cardiac dysfunction.Method:A total of 100 elderly patients with sepsis who entered the Emergency Room of Beijing Fengtai Hospital from January to August 2022 were selected and divided into two groups based on whether they had cardiac dysfunction:the cardiac dysfunction group(n=44)and the non cardiac dysfunction group(n=56).After the end of the study,patients were followed up for 28 d and divided into survival group(n=83)and death group(n=17)based on their survival status.The differences of B-type natriuretic peptide(BNP),cardiac troponin I(cTnI),serum procalcitonin(PCT),and sequential organ failure assessment(SOFA)scores in each group were compared,Pearson correlation coefficient was used to analyze the correlation between BNP,cTnI,PCT and SOFA in elderly sepsis patients with cardiac dysfunction.Result:The BNP,cTnI,PCT,and SOFA scores of the heart dysfunction group were higher than those of the non heart dysfunction group,the differences were statistically significant(P<0.05).The BNP,cTnI,PCT and SOFA scores of the death group were higher than those of the survival group,the differences were statistically significant(P<0.05).There were positive correlation between BNP,cTnI and PCT,SOFA scores in elderly sepsis patients with cardiac dysfunction(P<0.05).Conclusion:BNP and cTnI are positively correlated with inflammatory factors and prognosis in elderly sepsis patients with cardiac dysfunction,clinical monitoring of BNP and cTnI indicators can improve prognosis.