摘要
Irisin,a secreted myokine actively cleaved from fibronectin type III domain-containing protein 5(FNDC5),plays a crucial role in whole-body metabolism.To date,irisin receptor has not been identified,and its signal transduction is mostly unknown.Irisin is regulated by peroxisome proliferator-activated receptor-gamma(PPARγ)coactivator-1-alpha(PGC1α).
