中性粒细胞/淋巴细胞比值对急性大血管闭塞性卒中血管内治疗后症状性颅内出血的影响

Association between neutrophil/lymphocyte ratio and symptomatic intracranial haemorrhage in ischaemic stroke patients treated with endovascular treatment

目的探讨中性粒细胞/淋巴细胞比值是否与急性前循环大血管闭塞性脑卒中血管内治疗后患者症状性颅内出血相关。方法连续收集437例急性前循环大血管闭塞性脑卒中患者的临床资料,采用单因素分析及多因素Logistic回归分析评估中性粒细胞/淋巴细胞比值与急性前循环大血管闭塞性脑卒中血管内治疗后患者症状性颅内出血的关系。结果多因素Logistic回归分析显示卒中史及中性粒细胞/淋巴细胞比值是术后症状性颅内出血的独立危险因素。受试者工作特征(ROC)曲线显示,中性粒细胞/淋巴细胞比值预测血管内治疗后患者症状性颅内出血的曲线面积(AUC)为0.589(95%CI 0.509~0.688,P=0.029),最佳截止值为5.89,敏感度为65.00%,特异度为51.65%。结论中性粒细胞/淋巴细胞比值是导致急性前循环大血管闭塞性脑卒中血管内治疗术后症状性颅内出血的独立危险因素。

Objective To investigate the relationship between NLR and symptomatic intracranial hemorrhage(sICH)in patients with acute anterior circulation stroke undergoing endovascular treatment.Methods A total of 437 consecutive patients with acute stroke treated with endovascular treatment(EVT)were included.The patients were divided into two groups according to whether symptomatic intracranial hemorrhage was present.Univariate and multivariate analyses were performed.Results Compared with the non-symptomatic intracranial hemorrhage group.Multivariate Logistic regression analysis showed that the history of stroke and neutrophil/lymphocyte ratio were independent risk factors for postoperative symptomatic intracranial hemorrhage.The Area Under The Curve(AUC)value of NLR showed moderate accuracy,with an AUC value of 0.589(95%CI 0.509-0.688,P=0.029).The NSE cut-off value was set at 5.89.When the NLR≥5.89,the sensitivity was 65.00%,and the specificity was 51.65%(P=0.029).Conclusion Elevated NLR is an independent predictor for patients with acute anterior circulation stroke who are undergoing endovascular treatment.