摘要
嗜酸性粒细胞增多是蠕虫感染的重要特征。蠕虫造成的宿主上皮损伤能诱导2型免疫细胞的激活和分化。其中,嗜酸性粒细胞在细胞因子、趋化因子以及黏附分子的作用下发育成熟并募集到蠕虫感染部位,通过分泌一系列颗粒蛋白与免疫调节因子发挥免疫效应。本文就嗜酸性粒细胞和蠕虫之间关系的最新进展进行综述,探讨嗜酸性粒细胞对宿主的保护性免疫与病理损伤的两面性,及其对宿主机体的免疫调节作用。
Eosinophilia is an important characteristic of helminth infection.Injury of host epithelium caused by worms can induce the activation and differentiation of type 2 immune cells.Among them,eosinophils develop and mature under the action of cytokines,chemokines and adhesion molecules,and are recruited to the site of worm infection to exert immune effects by secreting a series of granule proteins and immune regulatory factors.This review examines the latest progress of the relationship between eosinophils and helminth,the duality of protective immunity and pathological damage of eosinophils on host,and immunomodulatory effect of eosinophils.
作者
刘祎琪
诸欣平
程喻力
LIU Yi-qi;ZHU Xin-ping;CHENG Yu-li(Department of Parasitology,School of Basic Medical Sciences,Capital Medical University,Beijing 100069,China)
出处
《寄生虫与医学昆虫学报》
CAS
2023年第1期59-64,共6页
Acta Parasitologica et Medica Entomologica Sinica
基金
北京市自然科学基金项目(7202008)。
