肺癌软脑膜转移诊治进展

Progress in diagnosis and treatment of leptomeningeal metastasis of lung cancer

肺癌是世界上死亡率最高的恶性肿瘤,严重威胁着人类的生命健康。肺癌软脑膜转移作为晚期肺癌的终末表现,由于临床表现缺乏特异性,神经影像学不敏感导致诊断困难。目前缺少系统的治疗方案及规范化的监测与管理,因而患者的整体预后较差。近年来,随着新技术的发展以及靶向、免疫药物的问世,肺癌软脑膜转移的诊断与治疗有了新的突破。本文将近年来发表的相关文章及重磅研究,按照驱动基因阳性的非小细胞肺癌、驱动基因阴性的非小细胞肺癌和小细胞肺癌三个方面对肺癌软脑膜转移诊治进展进行全面综述,以期推进肺癌软脑膜转移规范化诊治。

Lung cancer is a malignancy with the highest mortality in the world,posing a serious threat to human life and health.As the terminal manifestation of advanced lung cancer,leptomeningeal metastasis of lung cancer is difficult to diagnose due to the lack of specificity of clinical manifestations and insensitive neuroimaging.At present,there is no systematic treatment plan and standardized monitoring and management,resulting in poor prognosis of leptomeningeal metastasis of lung cancer.In recent years,with the development of new technologies and the advent of targeted and immune drugs,new breakthroughs have been made in the diagnosis and treatment of leptomeningeal metastasis of lung cancer.In this review,based on relevant articles and major studies published recently,the progress in the diagnosis and treatment of leptomeningeal metastasis of lung cancer was comprehensively reviewed from three aspects:non-small cell lung cancer with positive driver gene,non-small cell lung cancer with negative driver gene and small cell lung cancer,in order to promote the standardized diagnosis and therapy of leptomeningeal metastasis of lung cancer.