多索茶碱联合甲强龙治疗急性加重期COPD患者的疗效及对血清炎症因子水平的影响

Efficacy of Doxthelline Combined with Methyl Johnson in COPD Patients with Acute Exacerbation and Its Effect on Serum Inflammatory Factor Levels

目的以急性加重期的慢阻塞性肺部疾病患者为例,以其血清炎症因子水平、临床疗效为研究目标,分析联合开展多索茶碱和甲强龙治疗的作用价值。方法选取74例COPD急性加重期患者作为研究对象,按随机数表法1:1将患者划分两组,对照组(n=37)采用多索茶碱治疗,观察组(n=37)予以多索茶碱与甲强龙共同治疗,以治疗疗效、血清炎症因子和肺功能为判定指标,分析不同药物治疗后的效果。结果以治疗后为判定时间,临床疗效分析,对照组低于观察组,即83.78%<97.30%(P<0.05)。以治疗前为判定时间,患者肺功能指标、炎症因子水平比较,差异小(P>0.05);治疗后为判定时间,相比对照组,观察组更优(P<0.05)。结论对急性加重期的慢性阻塞性肺疾病患者采取多索茶碱联合甲强龙的临床治疗效果较为显著,有利于炎症因子的水平下降,肺部呼吸功能得到改善,临床应用价值较高。

Objective To analyze the value of chronic obstructive pulmonary disease patients with acute exacerbation and the serum inflammatory factor level and clinical efficacy as the goal of the combined treatment of doxophylline and mJ.Methods 74 Patients were divided into two groups according to the random table method 1:1.The control group(n=37)was treated with polytheophylline,and the observation group(n=37)was treated with polytheophylline,with therapeutic efficacy,serum inflammatory factor and lung function,and the effects of different drug treatment were analyzed.Results After treatment as the judgment time,the clinical efficacy analysis,the control group was lower than the observation group,i.e.83.78%<97.30%(P<0.05).Before treatment as the determination time,the difference between pulmonary function index and inflammatory factor level was small(P>0.05);after treatment as the determination time,and the observation group was better than the control group(P<0.05).Conclusion The clinical treatment effect of doxophylline combined with methylJohnson in patients with acute exacerbations is relatively significant,which is conducive to the decline of the level of inflammatory factors,the improvement of pulmonary respiratory function,and the high clinical application value.